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PENGARUH KUALITAS PRODUK DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN DI SITUS BELANJA ONLINE PADA MAHASISWA/I FEBI IAIN BATUSANGKAR

Tersedia Pada Ruang Karya Ilmiah Lantai 2

Teori Komunikasi Kontemporer

Seorang akademisi (dosen dan mahasiswa), praktisi ilmu komunikasi harus memahami secara jelas tentang bagaimana teori komunikasi dapat diimplementasikan dalam kehidupan nyata sesuai dengan paradigma yang dilihatnya. Memahami teori komunikasi baik yang kualitatif maupun kuantitatif akan memberikan warna bagi kehidupan seorang peneliti komunikasi dalam merangkai sebuah fenomena atau kejadian dari berbagai sudut pandangnya. Namun kita harus menyadari keterbatasan dari teori. Interaksi komunikasi terdiri atas banyak cara pandang, dan teori hanya menjelaskan sebagian dari kehidupan sosial yang kompleks. Buku ini dibuat dengan suatu keinginan penulis, agar pembaca bisa memahami pentingnya teori komunikasi yang dikaji baik secara ilmiah melalui pendekatan objektif dan pendekatan interpretif yang kini menjadi banyak perhatian bagi para kaum akademisi maupun praktisi ilmu komunikasi. Buku Persembahan Penerbit PrenadaMedia

Seorang akademisi (dosen dan mahasiswa), praktisi ilmu komunikasi harus memahami secara jelas tentang bagaimana teori komunikasi dapat diimplementasikan dalam kehidupan nyata sesuai dengan paradigma yang dilihatnya.

Sefer Pah蹋ad Yitsh蹋ak蹋

perush la-sefer "Otsrot H蹋ayim" she-hu ha-mahadura ha-tinyana shel ha-s. ha-k蹋. "驶Ets H蹋ayim" leha-Rav H蹋ayim V蹋it蹋al ... ha-perush kolel perush rahut蹋, be示urim v蹋e-驶iyunim, ma示amarim

Anti-cancer Activity of Triterpenoids Isolated from Luvunga Scandens Against MCF-7 Cells

Luvunga scandens belong to the family of Rutaceae which usually inhabits tropical and moist environment. This plant is known as 'Mengkurat Jakun' among locals and used traditionally to treat fever and fatigue via decoction. The study aimed to elucidate the compounds from L. scandens stem, which were isolated using bioactivity guided isolation together with their mechanism of action on human breast cancer cell (MCF-7). The bioactivity-guided isolation of cytotoxic agent of the stem of L. scandens resulted in the isolation and characterization of a new triterpenoid from this species, 3-oxotirucalla-7,24-dien-21-oic-acid (2), along with a known triterpenoid, flindissol (1). The isolation was conducted using chromatographic techniques on silica gel and sephadex LH-20. The structures of the isolated compounds were elucidated on the basis of spectroscopic analysis including UV, IR, NMR, MS and 2D NMR. The cytotoxic activity of the plant on the proliferation of MCF-7 cell line was evaluated by MTT, WST-1 assay, scanning electron microscope (SEM), flow cytometry and RT-qPCR. The cytotoxic evaluation of the extracts showed that IC50 value of the dichloromethane (LSC-SD) and methanol (LSC-SM) extracts from the stem were 75.0 and 77.0 μg/mL respectively. Whereas IC50 value of n-hexane (LSF-H), n-hexane:DCM (LSF-HD), DCM (LSF-D) and DCM:MeOH (LSF-DM) fraction extracts were 97.5, 35, 98.9 and 94 μg/mL respectively. The IC50 value of MeOH (LSF-M) fraction could not be extrapolated since none of the concentration of this extract was able to reduce the proliferation activity to 50 %. Compound 1 and 2 showed potent cytotoxicity against MCF-7 cell line with IC50 values of 13.8 μM and 27.5 respectively after 24 h of treatment. Doxorubicin was used as a positive control drug with IC50 values of 6.21 μM. Morphological analysis of the cells surface exhibit the apoptosis results after 24 h treated with LSC-SD extract, 1 and 2, where the cells were rounded up, shrank and lost contact with neighboring cells. Apoptosis of MCF-7 cells treated with both compounds were confirmed by flow cytometry. The results show that compound 1 and 2 exert their anti-proliferative effect on MCF-7 cells through inhibiting cell cycle where the distribution of cells at Sub G1 phase was 7.7 and 9.3 % respectively. Further evident of apoptosis induction by compound 1 and 2 towards MCF-7 cell lines were assayed by RT-qPCR on the expression of PUMA, caspase-8 and caspase-9. In this assay, both compounds showed the increased of the expression of PUMA, caspase-8 and caspase-9 gene. In conclusion, both triterpenoids, 3-oxotirucalla-7,24-dien-21-oic-acid (2) and flindissol (1) have a potential to be developed as anticancer agents against breast cancer.

Luvunga scandens belong to the family of Rutaceae which usually inhabits tropical and moist environment.

Design and Fabricate Tandem Bicycle

Front Part

This thesis deals with creating the tandem bicycle for 2 person. The objective of this thesis is to develop a procedure of creating this tandem bicycle that started with designing process till fabrication process. There is many type of bicycle created for certain activity. And every bicycle has its own characteristics. Objective of this project is to create a recreation tandem bicycle that can be use for outdoor activity and suit for adults and kids and can be ride with 2 person cycling. This tandem bicycle equipped with body stand seats that suits for an older person. The seats made using sponge and leather. This tandem bicycle also equipped with the foot rest for the rider to place their feet when not in cycling position while the other rider can continue cycling unmolested. The mobile phone charger using dynamo is placed on this bicycle for ease of the rider to charge their electronic devices that requires electricity without worrying run out of battery. The battery charger use the usb cable that produce limit with 5v of current supply.

This thesis deals with creating the tandem bicycle for 2 person.