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Sixty-one Years of University of Michigan Pharmacology

1942-2003

... computerized PowerPoint teaching slides (which a few faculty used instead of
sloppy hand-written overheads that looked like either they were put together
years before and never changed, or haphazardly assembled at the last minute
before a lecture). He built and equipped new clinical skills teaching labs; he
funded a major update to our Learning Resource Center, now stacked to the gills
with computers and other technologies for student learning and use, and good
support staff.

Pharmacology

Antioxidant and Antidiabetic Activity

In this present study, antioxidant potential of the methanol extract of the root of Cajanus cajan Linn (MCC-R) was identified by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay, Reducing power assay, total antioxidant activity test and also by total Phenolic content test. In DPPH scavenging assay the IC-50 value of the extract was found to be 17.44 g/ml while the IC-50 value of the reference standard ascorbic acid was 15.06 g/ml.Total antioxidant capacities of MCC-R is expressed as the number of equivalent of ascorbic acid 266.7mg/g and the reducing power of MCC-R increased with concentration of the sample. The amount of total Phenolic 262.31mg/g Gallic acid. These results suggest that the MCC-R providing potent antioxidant properties and offering effective protection from free radicals. Form this view point, MCC-R were tested for oral glucose tolerance test (OGTT) in normal mice. The postprandial blood glucose lowering effects of MCC-R (400mg/kg) were compared to a known type 2 diabetes drug (Acarbose-50mg/kg). The MCC-R were also tested alloxan (120 mg/kg) induced diabetic mice for 7 days.The blood glucose lowering effects MCC-----R (200mg/kg).

In this present study, antioxidant potential of the methanol extract of the root of Cajanus cajan Linn (MCC-R) was identified by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay, Reducing power assay, total antioxidant activity ...