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Analysis of Human Genetic Linkage

Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.

The LIPED program is still used by many researchers because it has been error
free for more than 20 years and because it is able to detect a large percentage of
errors in the input data by carrying out many checks for data consistency.

Handbook of Human Genetic Linkage

"A good reference for statisticians and other analysts becoming involved in the popular field of 'gene mapping'." -- American Journal of Human Genetics

LIPED (for LIkelihoods in PEDigrees) was the first generally available program
for linkage analysis (Ott, 1974). It has changed little since it was extended to
handle general pedigrees (Ott, 1976), except that age-of-onset functions were
later ...