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Linkage Thermodynamics of Macromolecular Interactions

This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

Because of its applicability to large systems and the availability of statistical error
bounds, a Monte Carlo program by Beroza et al. (1991) is employed for the
calculations that are reported below in Section III. It requires the standard pK.'s of
the ...