Science of Synthesis: Cross Coupling and Heck-Type Reactions Vol. 3

C-C Cross Coupling via C-H Activation

In "Science of Synthesis: Cross Coupling and Heck-Type Reactions", expert authors present and discuss the best and most reliable methods currently available for the formation of new carbon-carbon and carbon-heteroatom bonds using these reactions, highlighted with experimental procedures. The three volumes provide an extensive overview of the current state of the art in this field of central importance in modern chemistry, and are an invaluable resource for synthetic organic chemists. This volume covers the different classes of Heck-type reactions. It describes the developments in each area whilst critically evaluating the strengths and weaknesses of the different methods. Many of these newly developed Heck-type methods feature operationally convenient conditions, high catalytic efficiency, and high levels of chemical, regiochemical, and stereochemical control. // The content of this e-book was originally published in Dec. 2012.

R1 R2 Yield (%) Selectivity (β/α) Ref H H 53 3.0:1 [20] NO2 H 60 10:1 [20] Br H
55 2.5:1 [20] Cl H 60 3.0:1 [20] OAc H 40 2.7:1 [20] H Cl 43 3.7:1 [20] H NO2 44
4.0:1 [20] Reactions of aromatic acid chlorides with alkyl vinyl ethers in the
presence of a palladium catalyst and triethylamine to provide the βaroylated E-
vinyl ethers 14 in moderate to good yields have been reported (▷ Scheme 15).[
24] Relatively mild reaction conditions are used and a variety of substituents are
tolerated ...