Correlation Force Spectroscopy for Single Molecule Measurements

This thesis addresses the development of a new force spectroscopy tool, correlation force spectroscopy (CFS) for the measurement of the properties of very small volumes of material (molecular to μm3) at kHz-MHz frequency range. CFS measures the simultaneous thermal fluctuations of two closely-spaced atomic force microscopy (AFM) cantilevers. CFS then calculates the cross-correlation in the thermal fluctuations that gives the mechanical properties of the matter that spans the gap of the two cantilevers. The book also discusses development of CFS, its advantages over AFM, and its application in single molecule force spectroscopy and micro-rheology.

My perseverance, motivation, and ambition in this PhD thesis were due to a
supporting family that accompanied me every single day in the past few years,
although miles and miles away, but living with me and in my heart every single
minute. It is not easy to put into words, but simply, the years that I spent as a PhD
student in the Department of Chemical Engineering at Virginia Tech have been
the most inspiring and promising years of my life. I owe this invaluable
experience to the ...